Synthesis of <i>as</i>-Triazine Derivatives and their Antiviral Effect
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چکیده
منابع مشابه
Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors.
Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to that of the standard clorgyline, with apparently more selective inhibitory activity toward MAO-A th...
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BACKGROUND Replacement of chloride ions in cyanuric chloride give several variants of 1,3,5-triazine derivatives which were investigated as biologically active small molecules. These compounds exhibit antimalarial, antimicrobial, anti-cancer and anti-viral activities, among other beneficial properties. On the other hand, treatment of bacterial infections remains a challenging therapeutic proble...
متن کاملSynthesis of some new S-triazine based chalcones and their derivatives as potent antimicrobial agents.
Base catalysed condensation of ketone 5 with different aldehydes give chalcones, 2.4-bis-(phenylamino)-6-[4'-{3''-(4'''-substituted phenyl/2'''-furanyl/2'''-thienyl)-2''-propenon-1''-yl}phenylamino]-s-thriazines 6a-e. These chalcones on cyclization with hydrazine hydrate in the presence of glacial acetic acid, guanidine nitrate in the presence of alkali and malononitrile in the presence of ammo...
متن کاملSynthesis and anticancer evaluation of novel acenaphtho [1,2-e]-1,2,4- triazine derivatives
In this paper we present the convenient syntheses of seven new phenyl hydrazin derivatives 8 (a-h). For this purpose, acenaphtho [1,2-e]-1,2,4-triazine-9(8H)-thione (3) was prepared, starting from acenaphthylene-1, 2-dione (1) and thiosemicabazide in good yield. The reaction of (3) with benzyl chloride resulted to synthesis of 9-(benzylthio)-acenaphtho[1,2-e]-1,2,4-triazines (5) that reacted wi...
متن کاملSynthesis Optimization of Some Nucleoside Analogues Derivatives and Their Antiviral Activity
To prepare the target nucleosides, the branched chain sugars was converted to their active form (1-bromosugar derivatives). This conversion included the hydrolysis of bromination with hydrobromic acid (HBr) in glacial acetic acid, forming 1-bromo sugars (4,6-di-O-Acetyl-2,3-dideoxy-3,3-di-C-nitro methyl-Darabinohexopyranosyl bromide), which were subjected to condensation with theophylline mercu...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1960
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.80.8_1068